Metagenics Clinical Podcast

To all research enthusiasts - this is a fascinating podcast episode not to be missed! Associate Professor, Dr Karin Ried, explains NIIM’s Pathogen Blood Test, which involves innovative blood testing using cytology based microscopy, and genetic analysis to isolate and identify pathogens, such as Borrelia bacteria and fungi/mould, in the blood. Prepare to be blown away by the potential of this test! Introduction to the Pathogen Blood Test (4:00) Deep dive into the methods for identifying pathogens (14:00) Identifying stealth organisms (16:30) Insights from live microscopy (19:00) Is EBV at the helm? (21:00) Why supporting the immune system is the priority (24:50) Case Study – Rare fungal infection linked to juvenile arthritis (28:00) Intriguing insights about skin lesions (34:00) Focusing on Lyme like illness (39:30) The practicalities – what the report includes, and how to access it (51:45) Useful links and resources: https://www.niim.com.au/research/academic-staff/aprof-dr-karin-ried https://ww

Dr Nathan Bryan was the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health. Rose asks pertinent questions, and Bryan answers beautifully. Enjoy this highly informative conversation and take away a clear understanding of nitric oxide production and the importance of this molecule for health. What is nitric oxide and how do we make it? (3:00) Looking at the difference between nitrates and nitrites (10:15) The significance of the oral microbiome in the production of this molecule (17:30) The challenge with recommending nitrate enriched foods (24:00) The importance of nitric oxide for the body (28:00) Clinical symptoms that indicate nitric oxide deficiency (34:30) Fascinating results obtained from supplementation (37:00) What’s on the horizon for this field of research (42:40) Dr Nathan Byran - https://drnathansbryan.com/

In this episode, Nathan is joined by Dr Robert Hendren, a Professor of Psychiatry and Behavioural Science at the University of California, San Francisco and author of well over 100 scientific papers and five books. From the get-go, it is clear Hendren is deeply committed to his work, and as such, provides valuable insight into the complex pathology that is autism. Hendren speaks of his first clinical trial, which launched him on his current career path (2:00) Elucidating the etiology of ASD (6:00) Factors influencing gene expression (8:00) Looking to the mitochondria (11:00) The infamous gut-brain axis - what role does it play in ASD? (17:30) Environmental toxicity – do we treat it and if so, how? (26:00) Sulforaphane holds promise (31:20) Spotlight on metabolomics (34:00) Functional testing (38:50) Professor Hendren’s hopes for the treatment of ASD (43:50)

Professor Tommy Wood explains the effects of specific single nucleotide polymorphisms (SNPs) on an individual’s health outcomes. From his analysis of what has been presented in the literature and widely accepted in functional medicine circles, Tommy discusses the relevance of SNP testing and highlights the difference between “relative risk” and “personal risk” whilst expanding on additional factors that should take precedence when treating a patient.

Chris Masterjohn, PhD currently spends time on nutrition education, conducting independent research and consulting. He has deep and personal experiences with the power of food, movement, and mindfulness to support health and well-being. • How choline was recognised as an essential nutrient. (6.35) • Why choline reduces fatty liver. (11.52) • Dietary sources of choline and its relationship with betaine. (16.31) • Why the RDI for choline may not be enough. (20.53) • The relationship between methylation and choline. (24.49) • How to assess someone’s choline, B12 and folate status. (26.57) • The importance of choline in pregnancy and infancy. (36.09) • Teasing out the TMAO controversy. (41.17) • Optimising folate status: Interpreting testing and intake. (51.10) • Beyond folate forms: Addressing MTHFR SNPs with creatine, vitamin B2, choline and glycine. (53.45)

In this thought-provoking and highly informative interview, Nathan is joined by Ari Whitten – energy and fatigue specialist, and founder of The Energy Blueprint. Whitten gets real about the factors contributing to fatigue; dispelling common myths and reminding us about the importance of the universal basics to support energy production. When life intervenes, how Whitten found himself pursuing a career as an energy and fatigue specialist. (1:37) Does adrenal fatigue exist? (5:50) The relationship, or lack thereof, between cortisol levels and fatigue. (12:00) Why we should look to the mitochondria to understand fatigue (16:27) Is it worth testing for mitochondrial dysfunction? (28:18) Deliberating the value of screening for fatigue. (38:58) Assess and address circadian rhythm function (48:48) The importance of universal basics (53:25) The dance between antioxidants and pro-oxidants (1:02:00) Useful Links and Resources https://www.theenergyblueprint.com/

Take a trip down the vagal nerve with Nathan Rose and his guest Dr. Adrian Lopresti as they wander the landscape of strategies to stimulate this infamous pathway. Dr. Lopresti is a Clinical Psychologist in private practice, and senior researcher at Murdoch University with a host of published articles under his belt. Vagal nerve 101 (2:00) The relationship between heart rate variability (HRV) and vagal nerve activity (4:13) Dive into strategies to stimulate the vagal nerve (9:47) Take a breath for the vagal nerve (13:15) Why exercise is a useful tool (16:52) A spotlight on nutrients & diet (20:00) Is bioavailability of curcumin the be-all and end-all? (25:13) The current landscape on mood enhancing probiotics (29:16) Lopresti shares his thoughts on supporting HRV and vagal tone in clinical practice (36:09) Delve into Lopresti’s world – an update on research in action (38:40)

In this episode, Dr Erik Lundquist from the Temecula Centre for Integrative Medicine, shares the results and learnings of a recent trial using specialised pro-resolving mediators (SPMs) to address fibromyalgia symptoms. As Lundquist relays the details of the study, he offers a genuine account of his experience, bringing to light the complexities and realities of treating individuals living with fibromyalgia. While SPMs may not be a panacea, in his opinion, they are ‘an exciting new tool that we’re just scratching the surface on.’

Professor Serhan expands on the application of SPMs inside the inflammation-resolution cycle and outside this cycle, highlighting alternative mechanisms, the wide scope of SPM therapy and exciting new treatment considerations currently within the field of lipid research. Prof Serhan background on moving into studying lipid mediators. (1:30) Aspirin triggers biosynthesis of lipid mediators. (4:57) Old to new: Review of inflammation and stimulating resolution processes. (6:55) Resolvins reduce neutrophilic infiltration and inducing “self-limitation”. (11:14) Plasticity of macrophage poles – key function of SPMs. (13:48) Healthy human breast milk contains SPMs. (19:45) Structures, receptors and functional location of Resolvins. (20:44) Downregulation of biosynthetic enzymes and using SPMs. (25:00) Aged mice with enhanced inflammatory response and diminished resolution response. (29:00) SPMs in obesity models. (31:00) Role of SPMs in additional chronic inflammatory conditions. (40:05) SPM killing and cle

Dr Bill Harris has nearly four decades of experience as a lipid researcher and joins the podcast to discuss the benefits of the omega-3-index test. Listen to Dr Harris explain how the omega-3 index has demonstrated to be the best measure to date of omega 3 status and how this metric may be a more valuable marker of cardiovascular health than traditional biomarkers. Learn the nuances behind the mixed results of clinical trials of EPA/DHA for cardiovascular health, reinforcing the clinical efficacy of EPA/DHA supplementation. Hear Dr Harris’s surprising research findings on omega 6 status which makes you rethink the stereotype of omega 6 fatty acids.

Today Dr Ruscio clears a path to understanding the role of thyroid in any patient’s presentation. As usual, his approach is levelled at the most important testing whilst assessing patient’s diet and lifestyle for conservative treatments to save his patients time, money and their health. Challenging both standard and functional medicine approaches, he shares his evidence-based algorithm for thyroid management.

Dr Kara Fitzgerald joins Nathan Rose to discuss the epigenome, the effect of methylation on gene expression and looking at interventions outside the use of supplemental methyl donors to modify our epigenome for a healthy life.

Prof. David. O. Carpenter, MD, PhD (USA), Director of the Institute for Health and the Environment, is an internationally renowned expert in the human health effects of environmental contaminants, including non-ionizing radiation. He talks to Nathan Rose about his research and experience in dealing with sufferers of electromagnetic hypersensitivity (EHS) and other environmental intolerances.

Greg Potter PhD is a researcher and content director at HumanOS.me, an online platform helping people lead healthier lives. Greg’s thought-provoking research explores the associations between sleep duration, diet, physical activity and metabolic health. This podcast highlights the vital role sleep plays in health and the social influences that impact our sleep-wake cycle.

Northern Californian Doctor, author and medical consultant, Dr. Neil Nathan specialises in patients with serious, resistant chronic illness. In this podcast he discusses the clinical implications emerging from the Cell Danger Response, a revolutionary model developed by Dr. Robert Naviaux that explains how the body essentially gets “stuck” fighting a threat even after the danger has passed.

Dr Scott Kahan is the Director of the National Center for Weight and Wellness. A researcher, author, lecturer and experienced physician, he specialises in treating obesity. Dr Kahan balances the latest scientific approaches to treating obesity, with his passion for implementing behavioural changes.

Dr Tania Dempsey is an expert in chronic disease, autoimmune disorders, mast cell activation syndrome (MCAS), and the role these conditions play in hormonal disorders. Dr Dempsey is sought after internationally for her knowledge of chronic immune dysregulation, and uses Integrative Medicine to get to the root cause of disease.

Australian medical researcher, educator and author shares intriguing clinical insights from her research. She brings the neurobiology of appetite control to life, and explains how ‘diet breaks’ work to help people lose weight and keep it off. She also reviews the latest research on intermittent fasting and time restricted feeding to bring you up to date in obesity research.

Researcher, Neuroscientist and Author Stephan J. Guyenet has spent 12 years studying the neurobiology of body weight regulation. His book, The Hungry Brain, explores why many of our patients overeat, and provides practical, evidence-based strategies to overcome the hungry brain.