On Your Mind Neuroscience Podcast

This week on the On Your Mind Neuroscience Podcast: Let's take it from the ethics of genetic diagnosis all the way down to single RNA visualization this week.  Our papers examine the idea of RNA granules and impress us with their high resolution FISH.  We'll also talk about the idea of tenure, the biology of addiction and, apparently, the mathematically derived variations of tying a tie.  

This week on the On Your Mind Neuroscience Podcast: We’re probing the concept of the gut-brain axis and talking about the use of primates in genetic research, the responsibilities of scientific journalism and the gap between research and practice in veterinary medicine

This week on the On Your Mind Neuroscience Podcast We’ve got a double-header for you!  The papers that we’ve got on our minds use optogenetics to manipulate fear memory in the mouse hippocampus.  We’re also talking about primary care practitioners in mental health, the gender disparity in science and much more.

This week on the On Your Mind neuroscience podcast: We’re going back to basic science this week with a paper on dendrite regeneration by Stone et al.   We’ll also talk about the darkside of genius and the inspiring concept of a journal edited by kids, for kids. For shownotes and links to everything we've talk about today check out www.onyourmind.ca/destroying_dendrites

This week on the On Your Mind Neuroscience Podcast: The first OYM episode of 2014 is full of advice on how to pick a graduate advisor and succeed as a graduate student.  We’re talking about two recent advice articles in Neuron that have inspired us to take a look back at our own decisions and a the attention a Nobel winner has brought to the perils of Impact Factors.

No Neuroscience on this episode of On Your Mind, instead there there will be Adel singing and stories of Liam's loose relationship with pants. See you in 2014!

This week on the On Your Mind Neuroscience podcast: Alzheimers and the Garbage Barge.  Alzheimer’s disease and other neurodegenerative disorders are associated with amyloid plaques- aggregates of misfolded, aberrant proteins – throughout the brain. Our paper this week builds on the hypothesis that too much amyloid precursor protein (APP) is released from neurons because of impaired lysosome (Garbage Barge) functioning using Neu1 knockout mice. Also on our minds this week are computer models of peer review, medical hoaxes, and Vally-speak. For full show notes and links to everything we've talked about today head to www.OnYourMind.ca

On Your Mind Neuroscience Podcast: Can epigenetics explain behavioural inheritance between generations?  We’ll take a look at a paper by Dias and Ressler to help figure it out.  Also, we’ve got a lot to say about a paper claiming that the differences between men and women are, in part, due to the connectivity of their brain. For full shownotes and relevant links for this and every other episode go to www.onyourmind.ca

On Your Mind: Neuroscience insight, every week. This week we’re trying to unite genetics studies of autism and neurodevelopmental disorders with their associated gene networks with a paper by Willsey et al.  We’re also talking about the autrocities committed by American researchers in Guatamala in the 40s, the approach to AIDS treatment in Rwanda and the future of 23andMe. For full show notes and links head to www.OnYourMind.ca

Welcome to Jean-François Gariépy and Diana Xie from Neuro.tv!  Our guests drop by OYM headquarters (digitally, of course) to talk about the neural correlated of humor with a review by Vrticka et al.  We discuss the origins of humor as well as the challenges and rewards of trying to look at a living, functioning brain

Welcome to a very special episode of On Your Mind. This week Liam interviewed a bunch of students and post-docs that presented posters at SFN. These are there stories. Keith Hengen: Homoeostasis of neuronal spiking His Neuron Paper: (close access) Computer modelling shows the need for homoeostasis:  (Open Access)   Jonathan Michaels: Neural networks in grasping movements Multi-electrode array recording in monkeys - His Blog: ConciousMistakes.com   Anand Krishnan:  Peripheral nerve regeneration in mammals Nerve regeneration:   Nico Reggente: Diffusion Tensor Imaging in Value-Directed learning DTI: http://en.wikipedia.org/wiki/Diffusion_MRI Value Directed Decision Making: (closed access)   Elise Piazza : Hemisphereic Differences in Binocular Rivalry Binocular rivalry review   Martin Engel: Treating Schizophrenia with Neuregulin The state of current antipsychotics:

It’s all about the habenula on this episode of OYM.  We’re talking about a paper by Li et al. that deals with the role of the habenula in depression.   Also, we’ve got the cost of our science costs on our mind and we’re talking about the dangers of wreckless googling.

We’ve got our first ever guest host, Ian Mahar at OYM this week, talking neurogenesis in the hippocampus, antidepressants and the use of animal models of behaviour. Our tenth episode also has us talking about the pressure of huge conferences, the use of article-level metrics to evaluate a paper’s impact and a strange medical disorder.

This week we’re talking dopamine and dendritic spines with a well written paper by Jia et al.  We’ve also got a lot to say about visualizing science, conflicts of interest and the allure of being terrified

We’re talking epilepsy this week with a paper by Hunt et al. looking at GABA progenitor cells injected into the limbic system.  There’s also a thought provoking discussion of movies, the marketplace and our academic future in this special issue late-night episode.

We’ve got Rett syndrome on our mind this week and we’re discussing a paper that uses a clever gene editing technology in embryonic stem cells to study it.  We’re also talking about the allure of sexiness in science, the role of misfolded proteins in neurodegenerative disorders and what, if anything, distinguishes the brain of a genius.

This week at On Your Mind, we’re shedding some light on feeding behaviour with “The Inhibitory Circuit Architecture of the Lateral Hypothalamus Orchestrates Feeding” by Jennings et al.  It uses optogenetics and single cell gene expression to look at neural circuits in mice.  We’ve also got stress and the state of academia on our minds and we discuss all this from two different time zones at once!

We’re changing things up this week at On Your Mind and taking a more critical look at a paper that we’ve developed strong opinions about.  From the unnecessarily long title to the unfortunate lack of controls, we’ve got alot to say about “Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway” by Iafrati et al. (doi: 10.1038/mp.2013.66).  On the upside, this article is open access so we encourage you to download it and form your own opinions.  The authors do a series of behavioural, electrophysiological and pharmacological experiments using a mouse model that’s heterozygous for a functioning reelin gene.  Reelin is a protein that’s involved in guiding neural progenitors to their final destination, and seems to influence the maturation of NMDA receptors.  It has also been indirectly associated with a number of psychiatric disorders, including schizophrenia.  Mice that are heterozygous for r

This week on On Your Mind: It’s an OYM blast from the past with this week’s special-release, archived episode!   This episode starts out with a well-deserved congratulation to our very own Liam, for acing his PhD candidacy exam.  Now he’s formally allowed to do more work for no change in pay!  We also talk about how frustrating it can be when your experiments don’t work and how nerve wracking it is waiting for a funding decision.  This is the first (and hopefully last) episode where the “Kath-eter of science” makes an appearance and then it’s onto this week’s paper.   It’s called “Detection of Clinically Relevant Genetic Variants in Autism Spectrum Disorder by Whole-Genome Sequencing” by Jiang et al. doi:10.1016/j.ajhg.2013.06.012 This paper brings up some nostalgic flash-backs from Kat, who used to work in ASD research before taking the leap into grad school.  Autism spectrum disorders affect 1 in 88 children and are defined by deficits in social skills, communication and repetitive and restrictive interests