Betterhealthguy Blogcasts

Why You Should Listen: Why You Should Listen:  In this episode, you will learn about mast cell activation syndrome (MCAS) and some key considerations when treating this common issue seen in those with Lyme disease, mold illness, autism, and other complex conditions. About My Guest: My guest for this episode is Dr. Theo Theoharides.  Dr. Theo Theoharides, PhD, MD has studied the regulation of mast cell activation and its role in neuroinflammatory disease for over 30 years. He holds a Masters in Neuroimmunology, a PhD in Pharmacology, and an MD from Yale University.  He was the first to report that mast cells can secrete specific mediators selectively without degranulation, regulate blood-brain-barrier permeability, stimulate microglia, be activated by corticotropin-releasing hormone (CRH) secreted under stress to release VEGF selectively, be activated by synergistic action of CRH and neurotensin, be activated by IL-33 and substance P synergistically to secrete the pro-inflammatory cytokine TNF, secrete mitocho