Everything Hertz

79: Clinical trial reporting (with Henry Drysdale)

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Sinopsis

We chat with Henry Drysdale (University of Oxford), co-founder of the COMPare trials project (http://compare-trials.org), which compared clinical trial registrations with reported outcomes in five top medical journals and qualitatively analysed the responses to critical correspondence. Discussion points and links galore: The history behind the COMPare project The two papers that were published: a prospective cohort study (https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3173-2) correcting and monitoring 58 misreported trials and a qualitative analysis (https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3172-3) of researchers’ responses to critical correspondence Ben Goldacre's books (https://www.amazon.co.uk/l/B002C1VRBQ?_encoding=UTF8&redirectedFromKindleDbs=true&rfkd=1&shoppingPortalEnabled=true) What is outcome switching? What were some of the responses to query letters from the authors and journals? Misreporting trials (usually) doesn't lead to patient harm, but it ha