Metagenics Clinical Podcast

Professor Serhan expands on the application of SPMs inside the inflammation-resolution cycle and outside this cycle, highlighting alternative mechanisms, the wide scope of SPM therapy and exciting new treatment considerations currently within the field of lipid research. Prof Serhan background on moving into studying lipid mediators. (1:30) Aspirin triggers biosynthesis of lipid mediators. (4:57) Old to new: Review of inflammation and stimulating resolution processes. (6:55) Resolvins reduce neutrophilic infiltration and inducing “self-limitation”. (11:14) Plasticity of macrophage poles – key function of SPMs. (13:48) Healthy human breast milk contains SPMs. (19:45) Structures, receptors and functional location of Resolvins. (20:44) Downregulation of biosynthetic enzymes and using SPMs. (25:00) Aged mice with enhanced inflammatory response and diminished resolution response. (29:00) SPMs in obesity models. (31:00) Role of SPMs in additional chronic inflammatory conditions. (40:05) SPM killing and cle