Profile

The British artificial intelligence lab DeepMind have made an astonishing breakthrough in one of biology’s toughest problems. The firm announced this week that it had largely cracked the problem of predicting how proteins folds into unique shapes, a challenge scientists have been working on for 50 years. The discovery is expected to accelerate research into illnesses like cancer and Alzheimer’s, and could even help find solutions to climate change. Behind the project is DeepMind’s co-founder, Demis Hassabis. A former chess prodigy, Hassabis has always been captivated by games and the mental agility needed to play them. This fascination with the human mind inspired his determination to use artificial intelligence to solve the world’s problems.Producers: Ben Crighton, Viv Jones Editor: Rosamund Jones

This week the political turmoil at Number 10 has made the headlines. One of the prime minister's aides whose star appears to be on the rise is former journalist Allegra Stratton, the government's new press secretary. She'll be fronting televised briefings shortly. Becky Milligan examines her life and her career so far. Producers: Bethan Head and Sally Abrahams.

Early results from the world's first effective coronavirus vaccine showed it could prevent more than 90% of people from getting Covid-19.The vaccine had been developed by pharmaceutical companies Pfizer and BioNTech and was one of 11 vaccines that had reached the final stages of testing.Mark Coles explores the lives and careers of Ugur Sahin and Ozlem Tureci - the little known Turkish-German husband-and-wife team responsible for the development of the vaccine. First broadcast on Saturday 14th November 2020.Producers: Sally Abrahams and Ben Carter Editor: Rosamund Jones

As Wales eases its covid restrictions, Profile explores the life and various careers of the country's First Minister. Born and brought up in rural Wales, before entering the world of Labour politics Mark Drakeford worked as a social worker and an academic. And Mark Coles discovers that those are not his only interests. Tending his allotment, playing music and body boarding in all weathers also loom large. Presenter: Mark Coles Producers: Luke Radcliff and Ben Carter

The business woman and Great British Bake Off judge now working with the government to improve NHS food - her independent review demanding healthier meals for hospital patients. Born in South Africa, it was time spent in Paris which sparked Prue Leith's love of food. Transferring to London, she started a food empire in her bedsit, going on to open a catering college and a Michelin star restaurant. She took on public roles too, becoming the first woman on the board of British Rail, charged with fixing the network's food which had become a laughing stock.Prue built her media profile alongside roles in the arts, charity sector and education. Then after controversial team-changes in The Great British Bake Off, she's now become a bona fide celebrity, helping the hit programme reach record audiences. Producers: Richard Fenton-Smith & Ben Crighton Editor: Ros jones

The chief strategic advisor to PM Boris Johnson who thrives on getting things done and who was once regarded as Margaret Thatcher's favourite council leader.A former alarms company executive, Edward Lister's political career began in the London Borough of Wandsworth which was at the forefront of Thatcherism at the turn of the 1980s.A council leader for nearly two decades, he made the leap to City Hall when Boris Johnson made him his deputy - and he's been a trusted aide and fixer ever since.Despite his position, Sir Edward has kept a low public profile, working behind the scenes resolving recent Brexit stalemates. This week he's been the go-between in the negotiations between the government and city mayors in the North of England in the debate over the financial cost of Covid-19. Mark Coles profiles the life of the man described as the 'grown-up' at Number 10 who thrives on solving problems. Producers: Richard Fenton-Smith & Ben Crighton

The former bricklayer steering Liverpool through the latest coronavirus lockdown. Liverpool was the first region to face the toughest restrictions as the second wave of the pandemic takes hold. The man in charge of dealing with this new crisis is the first mayor of the city region, Steve Rotheram. Becky Milligan charts his rise, from a 16-year-old school leaver to prominent politician. Producer: Ben Crighton Researcher: Luke Radcliff

The man from Indiana who's "a heartbeat away" from the US presidency. Mark Coles tells the story of how a Catholic boy with Democratic Party leanings became a born-again evangelical and a hero of the Republican right. With President Donald Trump's recent bout with Covid-19, there has been more and more attention paid to the man next in line for the Oval Office. But there are doubts about whether a majority of the American public agree with the vice-president's strictly socially conservative views. Producer: Ben Crighton Researcher: Luke Radcliff

Billionaire Chuck Feeney said he would give away all of his money by 2020 – and he’s done it. An entrepreneur from childhood, he amassed a huge fortune in the duty-free business, before spending it on projects ranging from concert halls in Ireland to AIDS support in South Africa. For many years the money was only given out on condition of secrecy, that his name should never be mentioned in connection with the donations. Mark Coles finds out what’s driven this unique mission - and what his family think. Producer: Ben Crighton Researchers: Benita Barden & Beth Sagar-Fenton

Lewis Hamilton could be about to equal Michael Schumacher's incredible record of 91 Grand Prix wins - but can he achieve even more? The first black Formula 1 driver has been a champion since childhood, when he ran rings around the adults with his remote control car. Three decades on he's tipped to equal and even exceed the long standing record - but is he now determined to achieve as much off the track as on it? We hear from those who know Hamilton best, including an exclusive interview with his father, Anthony. Presenter: Becky Milligan Producer: Ben Crighton Researchers: Beth Sagar-Fenton & Benita Barden

The woman who could soon be "a heartbeat away" from the presidency. This week voters in some states started sending in their ballot papers for the US presidential election. If the Democrats win when results are announced in November, it's vice presidential candidate Kamala Harris who'll be second in line to the Oval Office. She would be the first black person, the first woman and the first person of Indian descent to become VP. But what is Kamala Harris really like? Why has she attracted criticism in some circles for her record as a prosecutor and a legislator, while being hailed a hero by others? And is she likely to attract voters to Joe Biden's presidential campaign, or drive them away? Presenter: Mark Coles Producer: Ben Crighton Researcher: Beth Sagar-Fenton

Why is the former Australian Prime Minister Tony Abbott such a controversial choice for trade adviser? Appointed by the Government to help negotiate post-Brexit deals for the UK, his supporters say he's a persuasive political operator and already has three free trade agreements under his belt. But others have been staggered by his appointment, saying he has a track record of sexism and homophobia, and will prove an "embarrassment" to the UK. Mark Coles speaks to colleagues, critics and even Abbott's sister to find out what drives the so-called "Mad Monk", and whether he'll make a success of the job. Presenter: Mark Coles Producer: Ben Crighton Researchers: Charlotte McDonald & Beth Sagar-Fenton Editor: Penny Murphy

Those in the know say he's "the ultimate keeper of secrets" - Simon Case was announced this week as the new Cabinet Secretary and head of the Civil Service. Aged just 41 and with a CV that takes him from GCHQ to Kensington Palace, he's now set to take on a role at the heart of government, heading up a workforce of more than 400,000 people. But with Covid an ongoing problem and Brexit on the cards - and without any experience of running a department - has the so-called "Rolls Royce of Sir Humphreys" got what it takes? Presenter: Mark Coles Producers: Ben Crighton & Beth Sagar-Fenton Editor: Penny Murphy

Health secretary Matt Hancock announced last week that Public Health England will be replaced with a new National Institute for Health Protection. Baroness Dido Harding, who ran NHS Test and Trace in England, will be heading up this new agency too, for now. Who is she? And why are some cynical about whether she'll be able to handle the new role?Dido Harding started out on a pig farm in Dorset, and has spent most of her adult life splitting her time between the corporate world and her beloved horses. Married to Conservative MP John Penrose, she's spent the last three years working in the public sector, and recently been a regular feature at Number 10’s daily coronavirus briefings. Mark Coles speaks to her best friend and former boss, amongst others, to find out more. Producer: Beth Sagar-Fenton Researcher: May Cameron Editor: Kirsty Reid

The no-nonsense scientist whose team is developing a coronavirus vaccine at record speed. Mark Coles discovers the many talents of Oxford University vaccine specialist, Professor Sarah Gilbert.Producer: Ben Crighton Researcher: Di Richardson

President Trump calls him a quality guy, others call him a dirty trickster. Mark Coles looks at the life of political strategist Roger Stone, who’s advised Republican politicians since the 1970s and proudly wears a tattoo of President Nixon on his back.Stone was convicted of lying to congress and witness tampering in 2019 but his sentence was commuted by President Trump, days before he was due to report to prison.This programme contains clips from Netflix Film Get Me Roger Stone. The writers are Morgan Pehme, Daniel DiMauro and Dylan Bank.Producer: Ben Crighton Researcher: Di Richardson

As the UK imposes sanctions on 49 people implicated in the deaths of Sergei Magnitsky and Saudi journalist Jamal Khashoggi, Mark Coles profiles the man whose global anti-corruption campaign has led to the government’s action, financier Bill Browder.Producer: Ben Crighton Researcher: Diane Richardson

As theatre bosses across the country warn they face devastation amid the coronavirus pandemic, actor Sir Ian McKellen is preparing to tread the boards in an age-blind interpretation of Hamlet. It will be one of the first major new theatre productions to start rehearsals in the UK since auditoriums went dark in March. The renowned theatre and film actor said he was happy to be working again in the role of the young prince he first played nearly 50 years ago. Becky Milligan speaks to close friends and colleagues, including Dame Judi Dench and Armistead Maupin, to find out what still drives him.Producer: Viv Jones

Boris Johnson says she’s a ‘brilliant thinker’ who inspires him. Now he has chosen Munira Mirza, the head of the No 10 policy unit, as the person to establish a new government commission on racial inequalities. Her appointment has proved controversial. Mirza has questioned the existence of institutional racism and criticised previous inquiries for fostering a “culture of grievance”. Her critics say her mind is already made up on the issues the commission will seek to investigate. Last weekend, Black Lives Matter demonstrators in London demanded her resignation. Mirza was raised in Oldham, became a supporter of the Revolutionary Communist Party as a student at Oxford, and eventually went to work for Boris Johnson after he was elected Mayor of London. Mark Coles profiles one of the government’s most influential advisers.

The Manchester United forward is credited with forcing a government U-turn this week, following his open letter calling on the government to end child poverty and extend free school meals for children during the summer holidays.Born in Wythenshawe and raised by a single mum, Marcus Rashford caught the eye of professional clubs at an early age. At first training with both Manchester City and Manchester United, he decided to dedicate himself to the Reds, and rapidly rose through the ranks. He debuted for the senior squad at 17 years of age, scoring twice, and scored again when he was first called up for England. A regular fixture for both United and England, he is now gaining attention for his philanthropic work, which is said to be inspired by the struggles he and his family faced when he was growing up.Producer: Richard Fenton-Smith