Sage Veterinary Science

A discussion with Drs. Nancy Everds, Nianyu Li and Katherine Sprugel from Amgen in Seattle, Washington about the article “Unexpected thrombocytopenia and anemia in cynomolgus monkeys induced by a therapeutic human monoclonal antibody”.  This manuscript won the journal’s best paper award in 2013 and describes a study that is a cautionary tale for those investigating/testing monoclonal antibodies.   Click here to read the full article.  

This podcast provides further insights on mitochondrial pathology resulting from long-term treatment of patients infected with human immunodeficiency virus using cocktails of nucleoside analog reverse transcriptase inhibitors (NRTIs).  The respondent is Dr. Brendan Payne, a clinician at the Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK with an interest in diagnosis and treatment of infectious disease--and specifically human immunodeficiency virus (HIV); Dr. Payne is the senior author of a recent review article, "HIV Treatment and Associated Mitochondrial Pathology: Review of 25 Years of In Vitro, Animal, and Human Studies."  Dr. Payne's research suggests that the cumulative exposure to NRTIs is more important than the peak levels, indicating that the usual design of animal experiments (short terms with high doses, histopathology as a major endpoint) to model human responses may understate or even miss the consequences to patients who may be expected to remain on cocktails of the

Veterinary Pathology podcast editor Leah Schutt talks with Duncan Lascelles about feline degenerative joint disease and his article “Pathology of Articular Cartilage and Synovial Membrane From Elbow Joints With and Without Degenerative Joint Disease in Domestic Cats,” from the September 2014 issue. To view this article, click here.

Anna Norman of SAGE talks with Susan Little about the development and significance of the recently published Feline-Friendly Nursing Care Guidelines - a joint initiative of the American Association of Feline Practitioners and the International Society of Feline Practitioners. Posted June 2012.

Jovie McMillan from SAGE talks to Hazel Carney about the AAFP and ISFM Guidelines for Diagnosing and Solving House-Soiling Behavior in Cats. Posted July 2014.

A discussion with Dr. Igor Mikaelian from AbbVie Bioresearch in Worcester MA about special issue 4 that focuses on drug induced vascular injury. The discussion centers on why drug-induced vascular injury in animals is an issue, why is it important when developing new pharmaceuticals, what efforts are underway to address human risk assessment of vascular injury, and how the articles in this issue benefit the pharmaceutical and biotech industries.   Click here to read the full article.  

Patricia Pesavento discusses the discovery, importance and pathogenesis of infectious diseases in animal shelters with Jeff Caswell. Dr. Pesavento and Brian Murphy authored the paper entitled "Common and emerging infectious diseases in the animal shelter" in the March 2014 special issue of Veterinary Pathology. Dr. Caswell co-edited the special issue on infectious diseases of domestic animals with Dr. Sean Callanan.     To view this article, click here.

Joshua Webster discusses the application and integration of nucleic acid-based molecular techniques in diagnostic pathology with Roger Maes and Matti Kiupel, who published the paper entitled "Beyond H&E: Integration of Nucleic Acid–Based Analyses Into Diagnostic Pathology" in the January 2014 special issue of Veterinary Pathology.  Dr. Webster co-edited the special issue focused on investigative techniques in pathology with Dr. Jose Ramos-Vara.     To view this article, click here.

Joshua Webster and Jose Ramos-Vara discuss immunohistochemistry protocol development, validation, and integration in diagnostic and investigative pathology, further expanding on Dr. Ramos-Vara's paper entitled "When Tissue Antigens and Antibodies Get Along: Revisiting the Technical Aspects of Immunohistochemistry-The Red, Brown, and Blue Technique" from the January 2014 special issue of Veterinary Pathology.  Dr. Webster and Ramos-Vara co-edited the special issue focused on investigative techniques in pathology.   To view this podcast, click here.