Sinopsis
For 50 years, Drug and Therapeutics Bulletin (DTB) has provided rigorous and independent evaluations of, and practical advice on, individual treatments and the overall management of disease for doctors, pharmacists and other healthcare professionals.DTB has always been wholly independent of the pharmaceutical industry, Government and regulatory authorities. DTB is also free of advertising and other forms of commercial sponsorship.
Episodios
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Rationalising blood tests, bempedoic acid and CV outcomes and semaglutide for obesity
30/11/2023 Duración: 26minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the December 2023 issue of DTB. They discuss monitoring drugs in primary care and the need to rationalise the number of blood tests undertaken (https://dtb.bmj.com/content/61/12/178). They talk about a study that reported the effect of bempedoic acid on a composite cardiovascular outcome (https://dtb.bmj.com/content/61/12/180). The main article is a review of semaglutide as an option for weight management and discusses the evidence for its use and some of the hype that has surrounded the its launch (https://dtb.bmj.com/content/61/12/182). They begin by responding to a listener's complaint about terminology. Related link: Aronson JK. When I use a word . . . Medicines regulation—apothecaries, quacks, chemists, druggists, pharmacists. BMJ 2023;383:p2603. https://www.bmj.com/content/383/bmj.p2603 Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also,
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BNF moving with the times; preventable deaths; plus an intro to pharmacogenetics
25/10/2023 Duración: 20minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the November 2023 issue of DTB. They discuss the history of the BNF and the announcement that the 86th edition of the BNF and the 2023–2024 edition of the BNF for Children will be the last print issues to be purchased by the National Institute for Health and Care Excellence for the NHS in England (https://dtb.bmj.com/content/61/11/162 and https://dtb.bmj.com/content/61/11/166). They talk about a retrospective review of a case series of UK coroners’ Reports to Prevent Future Deaths that found that around one in five reports involved a medicine (https://dtb.bmj.com/content/61/11/165). The main article provides an introduction to pharmacogenetics (https://dtb.bmj.com/content/61/11/168). They begin by responding to a listener's email. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcas
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Taxing ill health, and what evidence for intravenous vitamins?
27/09/2023 Duración: 16minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the October 2023 issue of DTB. They discuss NHS prescription charges in England and the impact they have on people with long-term ill health (https://dtb.bmj.com/content/61/10/146). They talk about a study that assessed the incidence of retinopathy associated with hydroxychloroquine (https://dtb.bmj.com/content/61/10/148). The main article discusses intravenous vitamins and reviews the evidence for their use for serious medical conditions and the evidence for their use in the absence of a specific vitamin deficiency or medical condition (https://dtb.bmj.com/content/61/10/151). The latest issue of Australian Prescriber mentioned in thia podcast is available from https://australianprescriber.tg.org.au/. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (htt
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NICE and redacted data, spironolactone for acne, and drugs with anticholinergic activity
30/08/2023 Duración: 28minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the September 2023 issue of DTB. They discuss concerns over redacted data in NICE appraisal documents (https://dtb.bmj.com/content/61/9/130). They review a placebo-controlled study that assessed the use of spironolactone for women with acne (https://dtb.bmj.com/content/61/9/132). The main article explores anticholinergic burden and the risk of cognitive decline, dementia and increased mortality associated with long-term use of drugs with anticholinergic activity (https://dtb.bmj.com/content/61/9/135). Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). If you want to contact us please email dtb@bmj.com. Thank you for listening.
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FeNO and asthma, low-dose aspirin and H pylori eradication, plus finerenone
26/07/2023 Duración: 24minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the August 2023 issue of DTB. They discuss measurement of fractional exhaled nitric oxide (FeNO) in the management of asthma (https://dtb.bmj.com/content/61/8/114). They review a study that assessed the use of H. pylori eradication in people taking low-dose aspirin (https://dtb.bmj.com/content/61/8/116). The main article explores the evidence for the use of finerenone for CKD associated with type 2 diabetes (https://dtb.bmj.com/content/61/8/120). Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). If you want to contact us please email dtb@bmj.com. Thank you for listening.
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July 2023: Whither evidence, COI in guidelines, isotretinoin safety, SGLT2 inhibitors and Utrogestan shortage
28/06/2023 Duración: 26minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the July 2023 issue of DTB. They discuss evidence-based medicine, access to evidence and increasing use of press releases and social media to present evidence (https://dtb.bmj.com/content/61/7/98). They talk about the safety of isotretinoin (https://dtb.bmj.com/content/61/7/99) and review a study that assessed the accuracy of conflict of interest statements in clinical guidelines (https://dtb.bmj.com/content/61/7/100). The main review article explores the evidence for cardiac and renal effects of SGLT2 inhibitors (https://dtb.bmj.com/content/61/7/103). They begin by discussing the impact of the shortage of Utrogestan.
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DTB 60th anniversary podcast interview - Barbara Mintzes
14/06/2023 Duración: 35minIn a series of podcasts to mark the 60th anniversary of DTB, we talk to some of DTB's Editorial Board members and other colleagues about their work and their involvement with DTB. In this podcast, David Phizackerley (DTB deputy editor) talks to Barbara Mintzes (DTB associate editor) who is Associate Professor at the School of Pharmacy and Charles Perkins Centre at the University of Sydney, where she has worked since 2015. Her background is in epidemiology and the main focus of her work is on pharmaceutical policy, including the effects of direct-to-consumer advertising and physician-directed promotion on medicine use. Barbara talks about her interest in medicines policies, the impact of pharmaceutical and medical device company payments to clinicians, medicalisation of normal life, medicine safety scandals and the impact on those who have been harmed by medicines with a particular focus on women's health. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device an
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Aciclovir PEP after VZ exposure in pregnancy, falls and fractures with aspirin, an inclisiran rant
31/05/2023 Duración: 33minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the June 2023 issue of DTB. They discuss new guidelines on post-exposure prophylaxis for varicella or shingles during pregnancy (https://dtb.bmj.com/content/61/6/82). They review the effect of low-dose aspirin on fractures and falls (https://dtb.bmj.com/content/61/6/85), and talk about a study that does not provide meaningful cardiovascular outcome data for inclisiran (https://dtb.bmj.com/content/61/6/86). The main review article explores hospitalisation as a consequence of medication-related harm and the need to reduce the burden of harm caused by medication (https://dtb.bmj.com/content/61/6/87). They begin by discussing an announcement from NHS England that antibiotics will be provided without the need for a prescription from community pharmacies to free up GP time. The contact address for the DTB team is dtb@bmj.com. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile devi
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May 2023 - another DTB celebration (or two), OACs and NSAIDs, and siRNA-based therapeutics
20/04/2023 Duración: 25minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the May 2023 issue of DTB. They celebrate 60 years since DTB became independent from The Medical Letter and discuss what DTB stands for (https://dtb.bmj.com/content/61/5/66). They review a retrospective cohort study involving people taking oral anticoagulants that compared the risk of bleeding and embolic events in new users of NSAIDs with those not prescribed NSAIDs (https://dtb.bmj.com/content/61/5/67). They also talk about the main review article that explores the therapeutics of siRNA medicines (https://dtb.bmj.com/content/61/5/72). They begin by discussing the UK Government’s recent Budget statement that the MHRA will introduce a new approval process for medicines that have been licensed elsewhere.
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When should you take antihypertensive medication. Prescribing for skin conditions in pregnancy
22/03/2023 Duración: 21minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the April 2023 issue of DTB. They discuss evidence around morning and evening doses of antihypertensive medication (https://dtb.bmj.com/content/61/4/50). They review a study that analysed health technology assessment decisions made in Australia, Canada and England (https://dtb.bmj.com/content/61/4/51) and also talk about managing skin conditions in women who are planning pregnancy or who are pregnant (https://dtb.bmj.com/content/61/4/55). They begin by responding to a listener's letter about last month's podcast. The Prescribing for pregnancy series of articles can be found here: https://dtb.bmj.com/pages/prescribing-for-pregnancy-series/
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DTB 60th anniversary podcast interview - Joanna Girling
08/03/2023 Duración: 36minIn a series of podcasts to mark the 60th anniversary of DTB, we talk to some of DTB's Editorial Board members and other colleagues about their work and their involvement with DTB. In this podcast, recorded May 2022, David Phizackerley (DTB's deputy editor) talks to Joanna Girling who is a consultant in obstetric medicine in north London and has been involved with DTB since 2006. Joanna talks about her clinical work, her role with establishing the local maternity network and her involvement in research. She also talks about supporting women who have pre-existing medical conditions and who are pregnant or who are planning pregnancy and the importance of checking that they are on the most appropriate medicines. The contact address for the DTB team is dtb@bmj.com. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-po
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Penicillin allergy, lecanemab and Alzeimer’s disease, a new oral contraceptive and statins for all
20/02/2023 Duración: 30minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the March 2023 issue of DTB. They discuss incorrect penicillin allergy labels and ways that these can be corrected (https://dtb.bmj.com/content/61/3/34). They review clinical trial results for lecanameb in early Alzheimer's disease (https://dtb.bmj.com/content/61/3/37) and also talk about a new combined oral contraceptive that contains estetrol and drospirenone (https://dtb.bmj.com/content/61/3/39). They begin by discussing a proposal from the National Institute for Health and Care Excellence to lower the threshold for offering statins for primary prevention. The contact address for the DTB team is dtb@bmj.com. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening.
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Swapping to edoxaban, DOACs in renal impairment, inflammatory rheumatic diseases in pregnancy
23/01/2023 Duración: 25minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the February 2023 issue of DTB. They discuss concerns over a national initiative in England to transfer people with atrial fibrillation to edoxaban from other DOACs (https://dtb.bmj.com/content/61/2/18). They review a study that examined whether the correct dose of DOAC was used in people with renal impairment (https://dtb.bmj.com/content/61/2/21). They talk about the use of empagliflozin in people with heart failure (https://dtb.bmj.com/content/61/2/22) and finish with an overview of an article that discusses prescribing for pregnancy for those with inflammatory rheumatic disease (https://dtb.bmj.com/content/61/2/24). 60th anniversary interview with Dr John Dowden: https://soundcloud.com/bmjpodcasts/dtb-60th-anniversary-podcast-interview-john-dowden Trends in direct oral anticoagulant (DOAC) prescribing in English primary care (2014–2019): https://heart.bmj.com/content/109/3/195 The contact address for the DTB
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DTB 60th anniversary podcast interview - John Dowden
12/01/2023 Duración: 35minIn a series of podcasts to mark the 60th anniversary of DTB, we talk to some of DTB's Editorial Board members and other colleagues about their work and their involvement with DTB. In this podcast, David Phizackerley (DTB's deputy editor) talks to Dr John Dowden, the editor of Australian Prescriber since 1990. Australian Prescriber (https://www.nps.org.au/australian-prescriber) is an independent peer-reviewed journal providing critical commentary on drugs and therapeutics for health professionals, and like DTB, Australian Prescriber was a founder member of the International Society of Drug Bulletins. At the time of recording, John highlighted that public funding for NPS Medicinewise (https://www.nps.org.au/), the organisation that publishes Australian Prescriber, was under threat and unfortunately the Australian Government withdrew funding and the organisation closed at the end of December. John and his team were made redundant, and the future of Australian Prescriber is uncertain. We wrote an editorial that
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Happy New Year, sad news from Australia, toxocarosis in humans and yet more on valproate safety
20/12/2022 Duración: 21minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the January 2023 issue of DTB. They begin with another reminder of the concerns over the use of sodium valproate. They talk about the closure of NPS MedicineWise in Australia and the uncertainty over the future of Australian Prescriber - https://dtb.bmj.com/content/61/1/2. They highlight the risk of eye problems with dupilumab - https://dtb.bmj.com/content/61/1/6 (see more links below) and the challenge of making sure that primary care clinical systems record drugs prescribed by specialists. They discuss toxocarosis in humans and the risk of environmental contamination from parasiticides used for deworming cats and dogs (https://dtb.bmj.com/content/61/1/3 and https://dtb.bmj.com/content/61/1/7). Dupilumab links: 1. Reji MA, Haque A, Goyal S, et al. Dupilumab-induced ocular surface disease: a primer. BMJ Case Reports CP 2022;15:e249019. https://casereports.bmj.com/content/15/4/e249019 2. Nahum Y, Mimouni M, Livny
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December 2022 - MHT and ’brain fog’, risks from sodium-containing paracetamol and 2022 revisited
22/11/2022 Duración: 25minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the December 2022 issue of DTB. They discuss cognitive changes that have been reported during the menopause and whether there is a role for MHT (https://dtb.bmj.com/content/60/12/178). They highlight an observational study that found an association between the use of sodium-containing paracetamol and cardiovascular events (https://dtb.bmj.com/content/60/12/181), and talk about the evidence for increasing the dose of vedolizumab in IBD (https://dtb.bmj.com/content/60/12/183). They begin the podcast by talking about their top three highlights from 2022. The contact address for the DTB team is dtb@bmj.com. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening.
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DTB 60th anniversary podcast interview - Jo Congleton
03/11/2022 Duración: 18minIn a series of podcasts to mark the 60th anniversary of DTB, we talk to some of DTB's Editorial Board members and other colleagues about their work and their involvement with DTB. In this podcast, David Phizackerley (DTB's deputy editor) talks to Dr Jo Congleton, who is a consultant in Integrated Respiratory Care in Brighton and Hove. She is also clinical lead for the Kent, Surrey, Sussex Academic Health and Science Network (AHSN) Respiratory Programme. Her interests are in chronic respiratory conditions (particularly COPD) and reducing both variation, and inequalities, in care. This special series of the DTB Podcast is produced by Leticia Amorim. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening.
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November 2022 - FMT, methotrexate and COVID vaccine boosters, and Palforzia for peanut allergy
26/10/2022 Duración: 30minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the November 2022 issue of DTB. They discuss the use of faecal microbiota transplantation to treat gastrointestinal infections and in particular its role in managing Clostridioides difficile infection (https://dtb.bmj.com/content/60/11/162). They highlight a study that assessed the effect of interrupting methotrexate treatment on COVID-19 booster vaccine response (https://dtb.bmj.com/content/60/11/163) and review a new drug that is licensed for treatment of patients aged 4 to 17 years with a confirmed diagnosis of peanut allergy (https://dtb.bmj.com/content/60/11/166). The podcast begins with the editors talking about the response to October's editorial "Stop advertising". Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/
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October 2022 - two freebies, advertising woes, paracetamol (again) and standing up to Pharma
26/09/2022 Duración: 32minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the October 2022 issue of DTB. They discuss whether the language used in announcements from organisations such as NHS England, NICE and the MHRA regarding new medicines is appropriate and highlight concerns that some press releases are at risk of promoting POMs to the public (https://dtb.bmj.com/content/60/10/146). They review a study that assessed the effect that regular doses of paracetamol had on blood pressure (https://dtb.bmj.com/content/60/10/147) and talk about an article that discusses the role played over the past 20 years by groups, organisations and individuals that have been critical of the pharmaceutical industry (https://dtb.bmj.com/content/60/10/151). Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-pod
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September 2022 - healthcare costs, gout, metformin and B12, more on COI and carbetocin
22/08/2022 Duración: 26minIn this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the September 2022 issue of DTB. They discuss a new national guideline on the management of gout (https://dtb.bmj.com/content/60/9/130). They highlight a safety update on the risk of vitamin B12 deficiency with metformin (https://dtb.bmj.com/content/60/9/131) and provide an overview of a study that analysed the way countries across Europe report payments made by pharmaceutical companies to healthcare professionals (https://dtb.bmj.com/content/60/9/135). They end the podcast with a discussion on the evidence for carbetocin in the prevention of postpartum haemorrhage (https://dtb.bmj.com/content/60/9/136). The contact address for the DTB team is dtb@bmj.com. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id30