Metagenics Clinical Podcast

Lara Briden is a naturopathic doctor and bestselling author of the book Period Repair Manual - a practical guide for treating period problems with nutrition, supplements, and bioidentical hormones. This year, Lara has released her new book, The Hormone Repair Manual, which explains how to navigate the change of perimenopause and relieve symptoms with natural treatments. In this episode, she explains the ins and outs of ‘second puberty’ and her favourite nutrients to support this time of life, as well as a fascinating evolutionary perspective on menopause. Tune in for a host of clinical gems! Highlights What motivated Lara to write The Hormone Repair Manual? (1:30) The perimenopausal years, aka ‘second puberty’ (4:00) Novel insights into nutrients for hormonal support (15:00) The recalibration process (19:00) Why you shouldn’t drink alcohol during perimenopause (25:30) Debunking the controversy surrounding phytoestrogens (29:00) The evolutionary take on menopause (33:00) Nutrients for perimenopause and menopau

Kara Fitzgerald and her research team were the first to demonstrate potential reversal of biological age in humans by targeting methylation. In their study, the prescribed program included multiple components with documented mechanistic activity on epigenetic pathways. Tune in to hear the details of her research and learn how to influence your epigenetics. Dr. Kara Fitzgerald has a doctorate of naturopathic medicine, and has been published in numerous peer-reviewed journals. She is on faculty at the Institute for Functional Medicine, and is an Institute for Functional Medicine Certified Practitioner. She regularly lectures internationally for several organizations and is in private practice in Sandy Hook, Connecticut. Highlights What motivated Kara to move into epigenetic research? (2:30) Introduction to epigenetic clocks (9:00) What positively impacts our epigenetics? (24:00) Kara details her research (30:00) Methylation adaptogens (35:00) Kara’s hopes for future research (45:00) *Useful Links and Resourc

As an expert in mast cell activation syndrome (MCAS), Dr Tania Dempsey, imparts priceless information regarding the nature and treatment of this insidious condition. Among many insights, Dr Dempsey explains how to distinguish histamine intolerance from MCAS, the impact of this condition on gastrointestinal health, as well as views on the connection between COVID-19 and MCAS. Importantly, Dr Dempsey draws on years of experience to provide advice on the identification and management of MCAS. Dr. Dempsey is Board Certified in Internal Medicine and a Diplomate of the American Board of Integrative and Holistic Medicine. She has served as an attending physician at a large multi-specialty medical practice in White Plains, NY, and since opened AIM Centre for Personalised Medicine. *Highlights * What is MCAS and how prevalent is it? (6:30) Examining the connection between gut health and MCAS (13:00) Histamine intolerance versus MCAS (21:30) Why a personalised diet is important (27:00) MCAS and COVID-19 (38:20) How t

Science educator, Jason Wilson is the host of The Curious About Cannabis Podcast which answers questions about the world’s most controversial plant – Cannabis. In this episode, Wilson provides an in-depth history lesson on Cannabinoid science, as well as the use of Cannabis extracts for medicinal purposes and the future of Cannabis research. Highlights: Jason’s journey to Cannabinoid research (1:30) A history lesson on Cannabinoid science (14:00) Examining endocannabinoid derangement and supplementation with phytocannabinoids (36:00) The entourage effect (45:00) Lesser known and emerging cannabinoids (55:00) Medicinal cannabis (1:02:00) Directions for future research (1:14:00) Useful links and resources: Follow Metagenics on Instagram here - https://www.instagram.com/metagenics_anz/ Or on Facebook - https://www.facebook.com/metagenics If you are a Healthcare Practitioner in Australia or New Zealand, keep up latest industry news and events by joining our private Practitioner Only Facebook Group - https://ww

Daniele Piomelli joins us from the University of California, Irvine, where he is the Louise Turner Arnold Chair in Neurosciences and Distinguished Professor of Anatomy and Neurobiology, Pharmacology and Biological Chemistry. Piomelli is the author of over 400 peer-reviewed articles in journals such as Nature, Science, Nature Medicine, PNAS and Nature Neuroscience, three books, and 34 patents. He is also the Director of the Centre for the Study of Cannabis and Editor-in-Chief of Cannabis and Cannabinoid Research, the first peer-reviewed journal entirely dedicated to the study of cannabis, its derivatives, and their endogenous counterparts in the human body. In this episode, he shares a wealth of information regarding the endocannabinoid system and the acylethanolamides, oleoylethanolamide (OEA) and palmitoylethanolamide (PEA). Highlights The endocannabinoid system (3:30) The fascinating history of PEA (25:50) The role of OEA in fat digestion (34:00) Zoning in on PEA (42:00) PEA dosage and time to benefit (5

Dr Tommy Wood earned his medical degree at the University of Oxford, and subsequently completed PhD in physiology and neuroscience at the University of Oslo. Currently, he holds academic positions at the University of Washington and Institute for Human and Machine Cognition. One of Dr Wood’s research interests is developing easily-accessible methods with which to track human health, performance, and longevity. In this episode, Dr Wood shares a plethora of information regarding the science of longevity, including patterns in ageing, determining biological age, and importantly, whether specific ingredients can increase longevity. *Highlights * The fascination with extending the lifespan (5:00) Looking to the Blue Zones (8:30) The biomarkers of ageing (15:50) Determining your biological age (21:00) Biological drivers of ageing (31:40) Diving into caloric restriction (38:00) Macronutrients for health and longevity (55:00) Ingredients to improve longevity (75:00) Useful links and resources: e.g: For

In this episode, Nathan had the honour of discussing intestinal permeability and ‘leaky gut’ with renowned gastroenterologist, Dr Eammon Quigley. He is internationally known for his research on gastrointestinal motility disorders, neurogastroenterology and the gut microbiome and has published more than 800 peer-reviewed articles, reviews, editorials, book chapters and case reports. Quigley is past president of the American College of Gastroenterology and the World Gastroenterology Organisation. His current responsibilities include, but are not limited to, the David M. Underwood Chair of Medicine in Digestive Disorders, Head of Gastroenterology and Hepatology at Houston Methodist Hospital, and Professor of Medicine at both the Institute of Academic Medicine and Weill Cornwell Medical College. *Highlights * Debunking the gut barrier (6:00) Evaluating tests to assess gut permeability (12:40) Does targeting paracellular permeability improve disease? (22:00) The role of the gut microbiome (29:20) Maintaining the

For anyone fascinated by the gut-brain connection, this episode is sure to pique your interest. Scott C Anderson is a scientist, science journalist and co-author of the book, The Psychobiotic Revolution. With great enthusiasm, he brings us up to speed on gut-brain axis centred research – from the relationship between gut health and depression, to the role psychobiotics and diet in the management of mental health conditions. ** Highlights ** Origins of research on the gut-brain axis (5:20) Chronic inflammation at the root of mood disorders (11:00) Markers used to assess gut health (14:30) The role of the vagus nerve in gut-brain cross-talk (21:20) Does poor gut health cause depression? (23:40) The relationship between gut health and ASD (28:00) Drawing our focus to cognitive health (33:00) What role does the small intestine play in disease? (37:00) Exploring the use of psychobiotics (42:30) Therapies to keep an eye on (57:25) Useful links and resources: e.g: Book –The Psychobiotic Revolution: Mood, Food, a

Looking for a novel approach to exercise for chronic disease populations? You’ve come to the right place. Nathan’s guest, Dr Brendan Scott provides a comprehensive review on blood flow restriction (BFR) training, a technique used to enhance muscular strength and hypertrophy through resistance and aerobic exercise. Dr Scott is a Senior lecturer in Strength and Conditioning at Murdoch University and has a keen interest in hypoxic and blood flow restriction training strategies. *Highlights * The origins of BFR training (6:05) What happens when you change blood flow characteristics (11:20) Benefits of BFR training (16:55) Using BFR in aerobic exercise (27:30) Safety concerns for this form of exercise (31:50) The equipment requirements (40:20) The future of BFR research (50:20) *Useful links and resources: * Dr Brendan Scott’s Murdoch University profile, and list of publications - http://profiles.murdoch.edu.au/myprofile/brendan-scott/ Join the Metagenics Practitioner Only Facebook Group here - https

Following his ME/CFS diagnosis 20 years ago, Ashok Gupta went on a journey to reclaim his health. His road to recovery emphasised the importance of retraining his brain and he subsequently created a 7-step program to promote neuroplasticity and support healing from chronic illness. In this episode, Gupta explains the basis for his hypothesis and shares an overview of the steps involved in the brain retraining process. A truly fascinating episode, you shan’t be disappointed! *Highlights * • Looking to the brain (2:55) • Gupta’s hypothesis - “we are survival machines” (4:30) • Why we need to address the cause of complaints (15:00) • Honing in on the amygdala and insular (17:00) • Fear extinction (27:00) • Retraining the brain (30:00) • Research results from amygdala and insular retraining (39:00) • Who would benefit from this program? (44:40) • How to sign up (53:20) Useful links and resources: e.g: https://www.guptaprogram.com/

Whether you’re intrigued by the science of sleep or simply looking for tools to improve your sleep quality, there’s no doubt you’ll appreciate this podcast episode. Nathan’s guest, Greg Potter, has a PhD in sleep patterns, dietary habits and metabolic health, and his research has been featured in the likes of TIME magazine and The Washington Post. Potter expertly answers all-important questions such as how much sleep do we actually need? What do sleep tracking devices offer? And how does CBT-I help in the quest for a good night’s rest? Enjoy the pillow talk with Greg Potter. *Highlights * • The impact of sleep on the immune system (3:10) • Night-time sleep affects day-time mood (8:00) • How much sleep do we actually need? (12:10) • Sleep and ageing (17:40) • Tracking your sleep (19:40) • Why you can’t sleep (30:00) • How to improve your sleep (34:30) • All about CBT-I (37:00) • Sleeping aids and supplements (52:15) Useful links and resources: e.g: CBT-I research links - Systematic Review and Meta-Analysis –

From 1994 until 2004 Jane McLelland battled two aggressive cancers with metastatic spread. Using her medical knowledge and researching heavily, she put together a cancer-starving formula, using natural therapies, exercise, diet and a unique cocktail of medications. Her personalised prescription saw her cancer “melt away”. Listen in to hear her remarkable story, and share her wisdom concerning cancer management. *Key Highlights * Jane McLelland’s story (1:55) How Jane created her famous ‘metro-map’ (17:00) Cancer fuel sources (24:00) Can we determine the fuel source for specific cancers? (30:00) Commentary regarding off-label drugs (38:00) Natural constituents (47:00) Drug recommendations (53:00) Ingredients critical to include in the cocktail (60:00) Useful links and resources: e.g: Jane McLelland’s website: https://www.howtostarvecancer.com/ Jane’s McLelland’s book - https://www.howtostarvecancer.com/the-book/

In his words, Dr Brad Dieter’s goal is to use analytics, data science, and a deep understanding of scientific principles to help solve advanced problems. With a background in exercise physiology, molecular biology and biostatistics, Brad proves an excellent guest, as he and Nathan cover the natural history of diabetes and screening tests to assess insulin resistance, to diet debates and the development of obesity – Is it simply a matter of calories in versus calories out? You will have to listen to find out! *Key Highlights * How Brad got started in this field (1:40) A pathophysiology lesson to start (5:10) Looking at the biomarkers (14:15) What drives obesity? Examining the hypotheses (20:00) Looking closer at diets (25:30) Transferring the research into clinic (36:40) Weighing up the ketogenic diet (40:40) Examining personalised nutrition (46:05) Useful links and resources: e.g: https://macrosinc.net/

Whether you are new to Emotional Freedom Technique (EFT), or are a seasoned ‘tapper’, this podcast episode is guaranteed to keep you engaged. Interviewee, Dr Peta Stapleton, is a clinical and health psychologist as well as associate professor in psychology at Bond University. Peta has led world-first randomised clinical trials investigating Emotional Freedom Techniques, adding a wealth of research to this field. *Key Highlights * The origins of EFT (2:30) What does a session involve? (6:10) Is tapping the acupoints essential? (8:35) The effect of EFT on physiology (13:00) Review of the research outcomes (17:30) The astonishing results for cravings and weight loss (27:00) Tapping as a tool for processing emotion (38:00) Navigating addiction with tapping (47:00) The practicalities – training and certification (51:00) Useful links and resources: Follow Metagenics Instagram - @metagenics_anz or Facebook - https://www.facebook.com/metagenics/ If you hold a Metagenics account in Australia or New Zealand

Back by popular demand! Associate Professor Dr Karin Ried joins Nathan to discuss the National Institute of Integrative Medicine’s ISET®-CTC test. Ried explains how the test detects CTCs, including how it can distinguish between malignant CTCs and benign circulating epithelial cells, as well as nuances around interpretation of results and the value of monitoring CTCs. Enjoy the highly informative conversation with Dr Ried. *Highlights * A very good place to start – what is a CTC? (1:30) The role the ISET®-CTC test has in integrative oncology (8:00) Nuances around result interpretation (12:40) Comparing this test to marker tests (21:20) Emphasis on the role of the immune system (29:50) Delivering results to patients (33:20) Delving into cancer screening (39:00) Learnings from examining prostate cancer (40:00) The value of monitoring CTCs (53:30) Therapeutic considerations (105:00) Useful links and resources: e.g: Follow Metagenics Instagram - @metagenics_anz or Facebook - https://www.facebook.com/me

Dr Mark Burhenne has been practising dentistry for over 30 years and is the author of the #1 best seller, The 8-Hour Sleep Paradox. His passion for oral health and the importance of healthy sleep shines through in this episode, as he offers important insights about the oral microbiome, P gingivalis and sleep apnoea. *Key Highlights * Burhenne’s short story (1:40) Welcome to the oral microbiome (6:10) Focus on P gingivalis (10:30) Can treating periodontitis improve other disease activity? (15:50) Conventional treatment for periodontitis (18:40) Natural considerations (23:30) All about biofilms and why we should reconsider using essential oils (26:45) Shining light on sleep apnoea (31:20) Why you should seek out a functional dentist (50:30) Useful links and resources: e.g: Dr Mark Burhenne’s website – https://askthedentist.com The 8-Hour Sleep Paradox: How We Are Sleeping Our Way to Fatigue, Disease and Unhappiness - https://www.amazon.com.au/8-Hour-Sleep-Paradox-Sleeping-Unhappiness-ebook/dp/B015D

Dr. Scott Antoine’s résumé includes 24 years practicing as an Emergency Medicine Physician and six years practicing Functional Medicine. As you can appreciate, he has a wealth of knowledge and practice under his belt, and is well placed to provide an update on Coronavirus pathophysiology and the role of potential therapies in preventing and managing the condition. *Key Highlights * • How Antoine found his way from ER to Functional Medicine (1:45) • The difficulty with examining the prevalence of Coronavirus (7:20) • Pathophysiology update (14:30) • Navigating therapies for Coronavirus (25:20) • The potential of Methylene blue (29:35) • The cytokine storm (35:50) • What can we do to prevent and manage Coronavirus? (41:20) • Special mention to quercetin (49:30) • Stress-related considerations (53:30) *Useful links and resources: * Link to Dr. Scott Antoine’s clinic: www.vinehealthcare.com Link to Antoine’s research – ‘A Literature Review Supporting the Addition of Intravenous Methylene Blue, High-dose Intraven

Coronavirus has brought about a great deal of changes and uncertainty in society. Rose sits down with clinical psychologist, Dr Adrian Lopresti, to discuss the mental and social implications of living with this pandemic. They discuss how to maintain a healthy mindset, including what to do and what not to do, as well as adjusting to new routines in lieu of this significant disruption to our lives. *Key Highlights * • The social and emotional toll of Coronavirus (3:00) • Practical strategies to help manage our exposure to information (8:00) • Incorporating an integrated approach for wellness (9:15) • Advice for our children (15:30) • Using the time to reflect (18:00) • Mindfulness practices (21:20) • Supplement considerations (25:40) • Establishing a new routine (28:30) • Dr Lopresti’s recent research and PI therapy (40:00) *Useful Links & Resources * https://pitherapy.com.au/

This episode provides a synopsis on the Coronavirus with a natural twist. Rose sits down with the perfect guest, Dr Heather Zwickey, who is both knowledgeable and articulate. Dr Zwickey has a PhD in immunology and microbiology, and is currently working as a professor and researcher examining the effects of natural medicines on the immune system. Key Highlights • Dr Zwickey’s origins in immunology (1:35) • Virus = SARS-CoV-2. Disease = COVID-19 (3:10) • Why is this virus more pathogenic than other viruses? (4:10) • What is emerging data telling us about the spread of this virus? (8:15) • COVID-19 in comparison to previous pandemics (9:55) • 48 hours from exposure to symptoms (11:30) • Who is at risk? (13:50) • Conventional treatments available for Coronavirus (22:55) • The potential of natural medicine (29:00) • Is there any risk in supplementing with vitamin D and zinc? (37:10) Useful link: https://heatherzwickey.com/

Research examining photobiomodulation, previously known as low level laser (light) therapy, shows promise for a wide range of ailments, from musculoskeletal complaints to degenerative diseases and psychiatric disorders. This episode covers all the basics and more, including a discussion regarding its mechanism of action and existing research as well as practical advice such as how to choose a light therapy device. Settle in as this podcast serves up a perfect introduction to photobiomouldation. *Key Highlights * • How Scott Nelson arrived in the world of photobiomodulation (3:20) • The foundations (6:30) • How the body harnesses and uses light energy (9:40) • Diving into the applications of light therapy (15:00) • Examining the clinical studies (19:40) • Psychiatric and cognitive health (20:50) • Pain and inflammation (31:00) • Cancer (33:00) • What else does photobiomodulation have to offer? (42:30) • Choosing a device for you and your patients (45:00) Useful links and resources: Light therapy device: Joo