Brains And Gains With Dr. David Maconi



On the Brains and Gains podcast, Dr. David Maconi discusses all things exercise science, nutrition, health, and personal development. Every week, Dr. Maconi invites health experts and thought leaders to share their expertise. Each episode ends with a charity donation to the charity of the guest's choice.New podcast weblog


  • Mike Israetel - Resensitization, Debating Joel Seedman and Doug Brignole, Placebo Effect

    14/11/2021 Duración: 01h07min

    Dr. Mike Israetel is back on to discuss the following: 0:00- Intro 0:30- Operation Smile 1:30- My decision to work with Steve Hall 2:30- Mike’s perspective on an advanced trainee switching to a methodical training system 8:30- How do you actually GET stronger for reps to cause muscle growth 15:05- Why Mike believes beginner naturals argue against traditional hypertrophy methods 17:45- Ego within lifting 25:00- Genetic predisposition to strength vs size 26:45- Injuries from more strength focused lifting 28:10- Different beneficial rep ranges 33:00- Resensitzation 35:50- Is the size vs strength discrepancy greater in enhanced lifters 42:00- Preferences toward training methods 43:00- Steroid placebo studies and my fake steroid study 50:20- Novelty as a stimulus 53:30- Doug Brignole and Joel Seedman 58:45- Back to placebo 1:01:30- Genetics vs effort 1:04:10- Where to find MikeMike's new IG:'s YouTube: htt

  • Dr. Ralph Esposito - Continuous Glucose Monitoring, Fasting, Rapamycin

    07/11/2021 Duración: 50min

    Dr. Ralph Esposito is back on the podcast to discuss the following:  0:00- Intro 1:00- Dr. Esposito’s background 3:30- What is truly evidence based? 9:00- Testing methods that are less “proven” 12:00- Rapamycin 16:00- Hormetic response of mTOR 19:55- Fasting 25:00- Continuous Glucose Monitors 36:30- My stories with measuring glucose and ketones 41:00- Being in true ketosis 43:20- Recent article on the carbohydrate – insulin modelDr. Esposito's IG: and Coaching: those looking to support the channel and our donations to various charities, please consider the above link to become a member and have the opportunity to appear on the channel!Patreon: Smile Fund: Homepage:

  • Dr. Thomas O'Connor - Shelby Starnes' Client Health Disaster

    22/10/2021 Duración: 43min

    Dr. Thomas O'Connor and IFBB Pro Jodie Engel join us today to discuss the medical complications Jodie has experienced in the past year after using extreme protocols given to her by her bodybuilding coach.  0:00- Intro 1:10- Jodie’s medical history and medications prescribed 6:40- Rhabdomyolysis diagnosis 9:00- Hospital admission 12:00- Blood work values 12:45- Dr. O’Connor gives his input 14:30- Powerlifters vs bodybuilders health risks 15:10- Holding coaches liable 18:10- More on Jodie’s current condition 21:00- Cardiac and renal diagnoses 24:40- Potential for return of cardiac health 25:50- Resting heart rate 28:00- Going to a university hospital 30:15- Dialysis  32:00- Ace inhibitors, angiotensin receptor blockers, beta blockers  35:15- Cardiac remodeling 37:30- Next steps for Jodie Dr. O'Connor's website: O'Connor's IG: O'Connor's YT:

  • Q&A 5 (Ft. Abel Csabai) - Artificial Sweeteners, Splitting Volume, Range of Motion

    09/10/2021 Duración: 01h07min

    We're back with our 5th Q&A, joined by Abel Csabai 0:00- Intro 1:00- Chasing hunger with artificial sweeteners 3:00- Shout out to Scott and Eric for their contribution 4:00- Abel starting his bulk 7:00- Working with a coach 8:00- Is straight protein ok pre-workout? 10:00- Leaning gaining rate of gain 12:00- Details on our training splits 18:00- Body measurements and discrepancies between appearance 22:30- Biomechanics of exercises / Doug Brignole  36:30- Water fluctuations and how it influences you 43:00- Intra-workout nutrition 49:00- How to break up back volume 52:30- Potential for human longevity 59:00- Pull up range of motion / stretch mediated hypertrophy 1:05:00- Hook grip vs mixed grip vs straps Website and Coaching: Smile Fund:

  • Abel Csabai & Brandon DaCruz- TRT, Genetic Distribution, Dealing w Injuries

    02/10/2021 Duración: 01h10min

    Brandon DaCruz and Abel Csabai are back on the podcast!0:40- Genetic freaks 7:00- TRT and Testosterone’s effect on muscle mass 11:00- More on genetic freaks15:30- Genetics vs PEDs20:00- Distribution of genetics 25:30- Exercise selection and variation 45:30- Are injuries in your old age worth it? 1:02:30- Have we found unique exercises make a difference 1:04:30- Shout out to Dr. Scott Stevenson1:09:35- Where to find more of Abel and Brandon Website and Coaching:'s IG:'s IG: Smile Fund:

  • Doug Brignole - Biomechanics of Lifting, Pain Free Lifting, Exercise Variations

    18/09/2021 Duración: 01h10min

    Doug Brignole is a former competitive bodybuilder, expert in biomechanics, author and public speaker. He has won numerous bodybuilding titles, including 1982 Mr. America and 1986 Mr. Universe. Today we dive into the following topics:  0:00- Intro 0:20- Operation smile 0:40- Hearing about Doug 1:30- Doug’s background 3:10- Defining inefficiency 7:40- Doug’s lifting background 9:20- Factoring in individual’s biomechanics 14:40- Lombard’s paradox and reciprocal innervation 17:45- Back to efficiency 22:20- Comparison to how many bodybuilders have grown with more traditional methods 25:20- Potential arguments against Doug’s methods 29:10- Knee issues with sissy squats 31:30- Using other exercises when there are issues  33:30- The Brig-20 35:50- 16 Factors 37:40- Where to find demonstrations and advice 38:30- Calves 42:30- Seated vs lying leg curl and comparison to overhead extension 49:50- Studies showing different growth in different areas of the muscle 53:45- Proximity to failure regardless of rep ra

  • Steve Hall - High Calorie Dieting, Gaining New Muscle, Winning His Show

    11/09/2021 Duración: 55min

    Steve Hall, founder of Revive Stronger, is back on the podcast! 0:00- Intro 0:20- Steve Hall on the podcast 2:00- The difficulty of cutting versus bulking 5:30- Mini cuts 10:40- Gaining new muscle versus retaining on muscle 12:40- Different levels of leanness 15:35- Steve’s calories 19:45- To refeed or not to refeed 22:30- Training while dieting 25:30- Issues with excessive exercise variation 34:30- Steve’s strength 42:15- Other camp’s trying these methods 44:30- Psychology of belief about your training 47:30- The steroid placebo stories and giving my brother fake steroids 49:15- Steve’s off season calories and difficulty eatingSteve's website:'s IG: and Coaching: Smile Fund:

  • Mario Tomic - Dangerous Lifting Stories, Skewed Strength Standards, Lifting for Life

    28/08/2021 Duración: 01h11min

    Mario Tomic is a fitness YouTuber, coach, and entrepreneur. Today we dive into the following topics: 0:00- Intro 0:40- Warped strength standards 1:40- Mario’s stats / lifting history 4:10- Dragonball Z / the heroes journey 8:00- Why lifting is enticing and creates a community 12:00- Mario’s stats / lifting history 16:00- Maximizing realistic life potential vs genetic potential 23:20- Realism versus social media expectations 25:10- Infinite game concept 28:00- Backing off the volume bandwagon 32:40- Finding ways to stay motivated for progress 40:40- Mario’s strength levels 47:00- Bulgarian split squats / leg exercises 54:30- Dangerous lifting stories 59:00- Regular gym vs social media standards 1:00:20- Strength vs size, skill vs inherent qualities 1:04:00- Low rep vs high rep strength 1:06:20- Relative strength 1:10:40- Where to find more of Mario Website and Coaching: Smile Fund:

  • Dr. Gary Linkov - More Plates More Dates, Hair Transplants, Body Dysmorphia

    14/08/2021 Duración: 01h04min

    Today we are joined by Dr. Gary Linkov. Dr. Linkov is double board-certified by the American Academy of Facial Plastic and Reconstructive Surgery and the American Board of Otolaryngology-Head & Neck Surgery.0:00- Intro0:20- Operation Smile1:00- YouTube algorithm growth5:40- Dr. Gary Linkov’s background11:50- More Plates More Dates 16:00- Finasteride / Propecia  21:30- PRP treatment for hair29:00- Transplanted hair taking on the qualities of other hair in the transplanted location30:00- Fees for hair transplants 31:15- Other professions doing botox and fillers36:10- Body dysmorphia / unhealthy psychology45:30- Comparing to social media 49:30- Feeling unhappy directly after surgery 53:15- Being treated based on how you look 55:30- Kybella 1:00:15- Buccal fat pad removal 1:03:50- Where to find more of Dr. Gary LinkovDr. Gary Linkov's IG: Gary Linkov's YT: Gary Linkov's Website: S

  • Geoffrey Verity Schofield - Invalid "Evidence Based" Advice, PED Users Forgetting Natural Training

    31/07/2021 Duración: 01h09min

    GVS is back! With the following topics:0:00- Intro0:30- More about Geoff2:40- Geoff’s response to training5:00- Learning one’s own response to training 11:45- Controversial advice about using the pump to determine training volume 15:30- Is RP becoming cultish?20:00- Nonsense content in the industry21:00- Bad advice from steroid using lifters 23:45- How long can you keep progressing?30:30- Genetic muscle shape36:00- Right vs left imbalances42:00- Female bodybuilders44:30- Is bodybuilding part of the fitness industry46:25- V-shred50:00- Geoff’s strength 1:04:00- Where to find GVS1:05:00- John Cena China controversyWebsite and Coaching: Smile Fund:

  • Greg O'Gallagher - Kinobody, Intermittent Fasting, Getting Brutally Strong

    23/07/2021 Duración: 51min

    Today we have on Gregory O'Gallagher, the founder of Kinobody, to discuss all of the following topics: 0:00- Intro 0:30- Charity Water donation1:30- Greg’s background 7:20- Greg’s height and weight8:20- MMA / Boxing training 10:10- Intermittent fasting popularization 19:20- When to workout when fasting 22:00- Greg’s impressive strength 29:30- How training changes as you become very advanced 34:00- The difficulty of cardio feats 38:15- The Kinobody personaGreg's Youtube:'s IG:'s Website: and Coaching: Smile Fund:

  • Q&A4 (Ft. Abel Csabai) - Who Cares Who's Enhanced, Tracking Calories, Training Splits

    17/07/2021 Duración: 01h02min

    We're back with our 4th Q&A, joined by Abel Csabai 0:00- Intro 1:00- Shout out to John D for membership to the Brains and Gains Podcast 1:50- When to start tracking calories in a diet 11:00- Using calipers to track body fat 12:20- Training with intent / perfect form all of the time 22:00- Benefits / advantages of different training splits 32:00- Is there a minimum daily volume required 35:30- Who cares who’s enhanced? 47:45- Can you do exclusively rest pause training?\ 55:00- Equating volume load Website and Coaching: those looking to support the channel and our donations to various charities, please consider the above link to become a member and have the opportunity to appear on the channel!Patreon: Smile Fund: Homepage:

  • Matt Terry on Drug Use in Olympics, Extreme Response to TRT, Genetic Response to Diets

    10/07/2021 Duración: 01h05min

    0:00- Intro 1:00- Matt Terry’s background 5:30- Credentials vs who is popular on social media 7:30- Drug use in the Olympics / at the elite level 12:40- Going on TRT 15:00- Subcutaneous vs intramuscular injections 18:15- Best powerlifting numbers 21:00- Weight to be contest lean vs bulked up 23:20- How PED usage changes perspectives 24:50- Delusional about PED’s effects` 36:00- Response to different diets 46:00- Step count 47:45- mTOR 51:30- How genes affect diet 54:50- What Matt found best training wise 57:15- What Matt found did not work well 58:00- Splits vs training variables 1:03:00- How to count volume 1:04:20- Where to find more of MattMatt's IG:'s Website: Smile Fund:

  • Lyle McDonald (Pt 2) on P-Ratio Debate, Refeed Updates, Regulating Volume

    02/07/2021 Duración: 01h01min

    This is part 2 to the podcast with Lyle posted last week. Topics below: 0:00- Intro 3:15- P-Ratio debate10:30- Practical vs theoretical issues bulking to high body fat percentages16:00- Set point changing and adding fat cells 20:14- Refeed research in recent years34:45- Lyle’s consultations38:45- Training volume regulations43:30- Lyle vs the fitness industry46:00- Who does Lyle think is smart in the industry?Lyle's Website: and Coaching: those looking to support the channel and our donations to various charities, please consider the above link to become a member and have the opportunity to appear on the channel!Patreon: Smile Fund: Homepage:

  • Lyle McDonald on Mike Israetel Debate, Defining Failure, When Lyle Has Been Wrong

    25/06/2021 Duración: 56min

    Lyle is back! And as usual it will be a two-parter. Part 1's topics below:0:00- Intro 1:15- The failure debate between Lyle McDonald and Mike Israetel6:50- The Lifting Dermatologist’s video16:30- How to prove Lyle wrong19:20- Defining failure 21:20- Issues with advice from enhanced lifters28:30- Variation in what failure looks like36:00- DC training 39:30- The evidence based community43:00- Rest pause variations53:00- When has Lyle been wrong55:00- What happened to Mark RippetoeLyle's Website: and Coaching: Smile Fund: Homepage:

  • Alberto Nunez - The Failure Debate, Back to Competing, Exercise Variation

    20/06/2021 Duración: 52min

    Today we Alberto Nunez of 3DMJ back on the podcast. Alberto has been lifting for over 20 years and has competed in natural bodybuilding for over 10, allowing him to gain multiple pro cards. Alberto has played a vital role in promoting the natural movement and his contributions as a coach, athlete, and author have helped propel some of the growth the sport has seen over the last decade. 0:00- Intro 0:20- Podcasting 3:00- Operation Smile donation 3:30- What Alberto has been doing bodybuilding wise 5:30- Ideal volume for someone experienced 6:20- The 3DMJ team competing together 8:30- The need for exercise variation 17:50- What progress looks like after being so advanced 24:10- What is Alberto doing differently this next contest season? 26:30- Cues for better focus 29:30- Pull Ups and Pull Up strength 34:40- Hesitancy to drop exercises 36:00- 500+lb squat 39:30- The failure debate  43:30- Having a competitive / athletic background 48:45- Gauging progress on certain momentum-prone movementshttps://3dmuscle

  • Geoffrey Verity Schofield - Censorship by Greg Doucette, Mike Israetel vs Lyle McDonald, Failure

    12/06/2021 Duración: 47min

    Today we're joined by Geoffrey Verity Schofield, a writer, coach, and brofessor of lifting. We dive into the following topics today:0:00- Intro 1:00- Unsolicited advice 4:30- Greg Doucette’s cookbook price 6:30- How to determine coaching prices 10:30- Is anyone buying these expensive products? 13:45- Athlean X’s fake weights 17:30- GVS’s start on YouTube 24:20- Do we put on an act? 31:55- Training talk / Geoff’s stats 36:10- Failure training 42:40- University studies 43:40- Mike Israetel vs Lyle McDonaldGVS's Charity Choice:'s Instagram:'s website: Website and Coaching: those looking to support the channel and our donations to various charities, please consider the above link to become a member and have the opportunity to appear on the channel!Patreon: 

  • Kolton Lukes on Leaving Natural Bodybuilding Behind, Delusional PED Users, Fake Gear

    05/06/2021 Duración: 47min

    Today we speak with bodybuilder and coach Kolton Lukes, discussing the following: 0:00- Intro 0:30- Kolton Lukes editing my videos 1:20- Cerebral Palsy donation 4:50- Kolton’s competition history 10:00- Taking the jump to enhanced bodybuilding 14:30- Determining why you have low testosterone 18:00- The dramatic effectiveness of blasting and cruising 22:40- The appeal of gear 24:30- The health risks of gear 28:00- bodybuilding progress versus other areas of life 35:30- Appearance suggesting how much knowledge you have 37:30- Dante Trudel’s influence 40:30- The availability of learning about PEDs online 43:00- Fake gear 47:20- Where to find Kolton for info and training  Kolton's IG: and Coaching: those looking to support the channel and our donations to various charities, please consider the above link to become a member and have the opportunity to appear on the channel!Patreon:

  • Menno Henselmans - Refeeds, P-Ratio Debate, Adaptable Metabolisms

    28/05/2021 Duración: 01h09min

    Menno Henselmans is the founder of the Henselmans Personal Training Certification Program (PT Course). He's a featured author in Men's Health, IronMind, T-Nation, AARR and many more. He is himself an experienced physique coach, including several pro card winning clients & international prize winners in physique sports and powerlifting. Today we discuss the following:0:00- Intro0:50- Nets to prevent malaria2:35- P-ratio debate with Gren Nuckols and Eric Trexler4:50- P-Ratio defined7:00- Menno’s volume recommendations and deloads13:20- Refeed debate and discussion 19:00- Adherence to diet 26:00- Refeeds to maintain versus diet down29:20- Water retention and bloating 33:10- Meal timing on workout days37:10- Adaptable metabolisms38:00- Poor estimates of body fat percentage  38:55- How I like to use calipers to gauge progress41:00- Menno’s height and weight 41:45- How Menno made new gains44:40- Sleep quality during dieting 46:30- Magnesium, melatonin, and light therapy54:00- Tips for dieting without

  • Bill Campbell on The Refeed / Diet Break Debate and Future Research

    22/05/2021 Duración: 47min

    Dr. Bill Campbell, Ph.D., FISSN, CSCS, is a Professor of Exercise Science and the Director of the Performance & Physique Enhancement Laboratory at the University of South Florida. His master’s and doctoral degrees were earned at Baylor University while serving as the Coordinator of the Exercise and Biochemical Nutrition Laboratory. He joined the faculty at USF in the Fall of 2007.As a researcher and author, Dr. Campbell has published more than 150 scientific papers and abstracts (in academic journals) related to sports nutrition and physique enhancement. In addition, he is a paid consultant to professional sport team organizations, sport entertainment corporations, and also is a litigation consultant and expert witness related to dietary supplementation. Dr. Campbell has published three books on sports nutrition, including the NSCA's Guide to Sport and Exercise Nutrition and Sports Nutrition: Enhancing Athletic Performance.His research is focused on improving exercise performance and enhancing physiq

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