Nature Podcast

In the past two years, there has been an explosion in the number of papers published relating to 'skeletal editing', a technique that allows chemists to precisely edit a molecule by deleting, adding or swapping single atoms in its core.Although many of these methods are early in development, researchers hope skeletal editing could revolutionize how organic chemists design molecules, dramatically speeding up the drug-discovery process.This is an audio version of our Feature: ‘Almost magical’: chemists can now move single atoms in and out of a molecule’s core Hosted on Acast. See acast.com/privacy for more information.

In this episode:00:46 Inside the brains of sleeping octopusesResearchers have probed the brains of octopuses and confirmed previous reports suggesting that these invertebrates have a two-stage sleep cycle similar to that seen in many vertebrates. The team suggests this system may have evolved independently in the two groups, as there are millions of years of evolutionary history between them. However, despite its presumed importance, it is a mystery why this system exists at all.Research article: Pophale et al.Nature Video: Do octopuses dream? Brain recordings provide the first clues10:37 Research HighlightsA huge volcano eruption that caused the most extreme lightning ever recorded, and a paper-inspired fabric that can keep you warm and cool.Research Highlight: Underwater volcano triggered the most intense lightning ever recordedResearch Highlight: Fabric warms or cools the body at the flick of a switch13:03 A hormone associated with more effective weight lossCalorie-restricted diets often lead to rapid weig

In this episode:00:45 Why losing the Y chromosome makes bladder cancer more aggressiveLoss of the Y chromosome in bladder cancer cells is associated with increased severity of disease, but the reasons behind this have been unclear. Now researchers show that the loss of this chromosome helps tumour cells evade the immune system. However, this mechanism also makes the cells more vulnerable to certain chemotherapy treatments, and the researchers hope their findings could help improve outcomes for patients in the future.Research article: Abdel-Hafiz et al.07:30 Research HighlightsHow pollution particles ferry influenza virus deep into the lungs, and why artificial lights could dazzle glow worms into extinction.Research Highlight: Flu virus hitches a ride with haze particles deep into the lungResearch Highlight: Glow-worms’ ‘come-hither’ signals are lost in the glare of human lights10:10 Engineering synthetic cartilageThe cartilage in our joints is able to withstand and dissipate a lifetime of impacts, protecting

In this episode:00:47 How to make quantum computers ready for real world applicationsQuantum computers have long held the promise of being able to perform tasks that classical computers can’t. However, despite this promise, there have been few applications that can only be accomplished by a quantum computer. Now though, researchers show that a quantum computer can resolve a physics problem concerning the orientation of quantum particles in a 2D material, which is difficult to accomplish with a ‘regular’ machine. They hope that this shows how quantum computers could be applied in real world research applications in the near future.Nature News: IBM quantum computer passes calculation milestoneResearch article: Kim et al.News and Views: Quantum computer scales up by mitigating errors10:11 Research HighlightsHow some bacteria turned their defences into weapons, and a forecast of how quickly arctic sea ice will disappear.Research Highlight: Cholera bacteria turn slime into an offensive weaponResearch Highlight: Th

In this episode:00:46 The mouse brain circuit controlling infanticidal behaviourIn mammals, infanticide is a relatively common behaviour, but not a default one. For example, virgin female mice will often kill young produced by other females, but this behaviour disappears when they become mothers themselves. To understand this switch, researchers have identified a brain circuit associated with infanticidal behaviour that gets switched off after mice give birth. They hope that by better understanding this circuit it could inform why animals engage in such behaviours.Research article: Mei et al.Research Briefing: A battle between neural circuits for infanticide and maternal-care behaviours08:11 Research HighlightsThe cyclone raging at the north pole of Uranus, and the ants that build landmarks to help them find their way home.Research Highlight: A storm is whirling atop UranusResearch Highlight: These hardy ants build their own landmarks in the desert10:52 Getting to the source of fast solar windThe sun produces

In this episode:00:46 An AI that predicts gene interactionsMapping the network of genes that control cellular processes can be difficult to do when gene-expression data is sparse, such as in rare diseases or those affecting tissues that are hard to clinically sample. To overcome this, a team has developed an artificial intelligence system trained on a large, general dataset, and used it to make predictions about gene interactions in data-limited situations. As a test-case they look at the heart condition cardiomyopathy, and show that the system can identify potential interactions that could represent new therapeutic targets.Research article: Theodoris et al.09:08 Research HighlightsMicrobes that can break down persistent ‘forever chemicals’, and why intermolecular distances are the key to keeping gummy sweets chewy.Research Highlight: Microbes take the ‘forever’ out of ‘forever chemicals’Research Highlight: Better gummy sweets are within reach, thanks to physics12:06 Briefing ChatWe discuss some highlights fr

Shocked by the impact of online misinformation surrounding the COVID-19 pandemic, several researchers are launching efforts to survey scientists’ thinking on issues from vaccine safety to climate change. They hope that their projects will make scientific debate, and degrees of consensus, more visible and transparent, benefiting public conversation and policymaking. However, others suggest that these attempts might merely further politicize public debate.This is an audio version of our Feature: Can giant surveys of scientists fight misinformation on COVID, climate change and more? Hosted on Acast. See acast.com/privacy for more information.

In this episode:00:45 Tree islands bring biodiversity benefits for oil-palm plantationGlobal demand for palm oil has resulted in huge expansion of the palm plantations needed to produce it, causing widespread tropical deforestation and species loss. To address this, researchers planted islands of native trees among the palms in a large plantation, and showed that this approach increases ecosystem health, without affecting crop yields. The team say that while protecting existing tropical rainforests should remain a priority, tree islands represent a promising way to restore ecosystems.Research article: Zemp et al.09:42 Research HighlightsThe oldest identified ‘blueprints’ depict vast hunting traps with extraordinary precision, and fossil evidence that pliosaurs swimming the Jurassic seas may have been as big as whales.Research Highlight: Oldest known ‘blueprints’ aided human hunters 9,000 years agoResearch Highlight: This gigantic toothy reptile terrorized the Jurassic oceans12:08 Briefing ChatWe discuss some

In this episode:00:46 What JWST has revealed about an ancient galaxyResearchers have pointed the James Webb Space Telescope (JWST) at JD1, one of the universe's most distant known galaxies. The power of JWST has filled in some of the gaps in what was known about the galaxy, giving greater insight into its age, structure and composition. The team behind the work hope that learning more about how early galaxies like JD1 formed will help explain how the universe evolved into its present state.Research article: Roberts-Borsani et al.10:09 Research HighlightsWhy your choice of soap might make you irresistible to mosquitoes, and how tardigrade-inspired claws help tiny robots cling to blood-vessels.Research Highlight: Your favourite soap might turn you into a mosquito magnetResearch Highlight: Claws like a tardigrade’s give swimming microrobots a grip12:34 How coral reef fish evolved to grow more quicklyFish that live in coral reefs are some of the fastest growing in the world, despite the environment they live in b

Many researchers have been critical of the biases that the publication process can introduce into science. For example, they argue that a focus on publishing interesting or significant results can give a false impression of what broader research is finding about a particular field.To tackle this, some scientists have championed the publication of Registered Reports. These articles split the peer review process in two, first critically assessing the methodology of a research study before data is collected, and again when the results are found. The idea being to encourage robust research regardless of the outcome.In this episode of Nature's Take we discuss Nature's recent adoption of the format, the pros and cons of Registered Reports, and what more needs to be done to tackle publication bias. Hosted on Acast. See acast.com/privacy for more information.

In this episode:00:45 Making a more diverse human genomeThe first draft of the human genome ushered in a new era of genetics research. Since its publication, researchers have constructed ever more accurate ‘reference genomes’ – baselines against which others are compared. But these are based on the DNA of a small number of people, and don’t represent the genetic variation known to exist across human populations. To address this, a consortium of researchers have published the first draft of a ‘pangenome’, which combines the genomes of 47 genetically diverse individuals. This draft provides a more complete picture of the human genome, and is the starting point for a project that aims to include sequences from 350 individuals.Research article: Liao et al. Research article: Vollger et al.Research article: Guarracino et al.News and Views Forum: Human pangenome supports analysis of complex genomic regions08:33 Research HighlightsA wearable sensor that lets users see infrared light, and how a vulture’s culture can i

In this episode:00:47 A focus on women’s healthNature’s Kerri Smith and Heidi Ledford join us to discuss two Features published in Nature looking at topics surrounding women’s health. The first looks at efforts to understand how menopause affects brain health, while the second takes a deep-dive into research funding and shows how conditions affecting women more than men receive less money.Feature: How menopause reshapes the brainFeature: Women’s health research lacks funding – these charts show how18:15 Research HighlightsThe herb that could be a new source of cannabinoid compounds, and the vibrating crystal that confirms Schrödinger’s cat.Research Highlight: Old and new cannabis compounds are found in an African herbResearch Highlight: Schrödinger’s cat is verified by a vibrating crystal20:34 The planet swallowed by a starStars have a finite lifespan, and for many their fate is to expand as they reach the end of their lives. It’s long been speculated that these growing stars will consume any planets in their

Last year, researchers announced that the Alzheimer’s drug lecanemab lowered the amount of amyloid protein plaques associated with the disease in the brains of participants in a clinical trial, and slowed their cognitive decline.Now, researchers are looking to drug combinations, vaccines and gene therapy to tackle different stages of the disease, as they forge the next generation of treatments for the condition.This is an audio version of our Feature: Conquering Alzheimer’s: a look at the therapies of the future Hosted on Acast. See acast.com/privacy for more information.

In this episode:00:57 Franklin’s real roleWhen it comes to the structure of DNA, everyone thinks they know Rosalind Franklin’s role in its discovery. The story goes that her crucial data was taken by James Watson without her knowledge, helping him and Francis Crick solve the structure. However, new evidence has revealed that this wasn’t really the case. Rosalind Franklin was not a ‘wronged heroine’, she was an equal contributor to the discovery.Comment: What Rosalind Franklin truly contributed to the discovery of DNA’s structure13:41 Research HighlightsHow the growth of tiny iodine-engined satellites could damage the ozone layer, and how a pill-like detector that could measure radiotherapy dosages.Research Highlight: How CubeSats could harm the ozone layerResearch Highlight: An easy-to-swallow pill monitors X-ray dosage16:06 Why multisensory experiences can make stronger memoriesIt’s recognized that multisensory experiences can create strong memories and that later-on, a single sensory experience can trigger

In this episode:00:45 A new method to break down plastic polymersPlastic waste is an enormous problem, with much of it being incinerated or ending up in landfill. One way to give plastics another life is to break them down into their individual components using heat, but this method yields low amounts of usable product. Now, a team demonstrates a proof-of-concept method of heating that wicks the plastic like a candle through a layer of carbon material. They show that this method is more efficient and could be an additional way of breaking down waste plastics.Research article: Dong et al.08:48 Research HighlightsPhysicists model the best way to soar on a playground swing, and how wearing ‘perfume’ helps male orchid bees find a mate.Research Highlight: Physicists’ advice on how to swing high at the playgroundResearch Highlight: Better than Chanel: perfumed male bees draw more mates11:20 Briefing ChatWe discuss some highlights from the Nature Briefing. This time, the runaway supermassive black hole that’s racing

In the latest episode of Nature hits the books, psychologist Sander van der Linden joins us to discuss his new book Foolproof, which focuses on misinformation and what can be done to prevent people being duped, particularly by the falsehoods found online.We discuss how misinformation messages are crafted, why they can be hard to shake once someone is exposed, and how Star Wars: Episode 3 helped in the fight against them…Foolproof, Sander van der Linden, Fourth Estate (2023)Music supplied by Airae/Epidemic Sound/Getty images. Hosted on Acast. See acast.com/privacy for more information.

00:44 The unusual receptors that let octopuses hunt by touchResearchers have shown that the suckers of octopuses are covered with specialised receptors that allow them to taste by touching things. Similar receptors are also found in squid, but there are differences that mirror differences in the animals’ hunting behaviours; while octopuses feel for their prey, squid pull things towards themselves before deciding whether or not to eat it.Research article: Kang et al.Research article: Allard et al.Nature video: How octopuses taste with their arms08:48 Research HighlightsHow climate change has been linked to a devastating avalanche in the Italian Alps, and evidence of hallucinogenic drug use in prehistoric Europe.Research Highlight: A glacier’s catastrophic collapse is linked to global warmingResearch Highlight: Hair buried in a cave shows hallucinogen use in ancient Europe11:31 Briefing ChatWe discuss some highlights from the Nature Briefing. This time, what climate scientists can learn from medieval descriptio

00:46 A pair of supermassive black holes in the distant universeSupermassive black holes are found at the centre of galaxies across the universe. But observations of galaxies with more than one – caused by the merging of two galaxies – have been rare. Now, researchers have combined data from a number of telescopes and satellites, to reveal a pair of supermassive blackholes farther from Earth than any pair detected previously. They hope this will offer insights into how galaxies form.Research article: Chen et al.News and Views: Distant supermassive black holes spotted in galaxy merger10:53 Research HighlightsWhy appetite can increase after dieting, and gliding mammals’ flight-associated genes.Research Highlight: Can’t keep off lost weight? Blame your ‘hunger cells’Research Highlight: How gliding mammals developed the flaps for ‘flight’13:35 A clinical trial of an AI heart assessorA team of researchers and clinicians report results of a clinical trial designed to test the ability of an AI to accurately interpre

Last month, a magnitude-7.8 earthquake struck Turkey and Syria, killing an estimated 50,000 people. Two decades ago, researchers suggested that an earthquake in this area was likely, but exactly where and when it would strike were unknown.This shows both the promise — and limitations — of the science of earthquake forecasting. Years of research suggest that it may be impossible to predict exactly when an earthquake will occur. As a result, many in the field have now shifted to identifying high risk fault segments to help policymakers take steps to avoid death and destruction.This is an audio version of our Feature: What Turkey’s earthquake tells us about the science of seismic forecasting Hosted on Acast. See acast.com/privacy for more information.

00:48 Tiny syringes for drug deliveryA team of researchers have repurposed tiny syringe-like structures produced by some bacteria to deliver molecules directly into human cells. They hope that this method could be used to overcome a big challenge in modern medicine, namely ensuring that therapeutics are delivered into the precise cells that need to be treated.Research article: Kreitz et al.News and Views: Mix-and-match tools for protein injection into cells07:05 Research HighlightsA diamond-like material could protect spacecraft from intense radiation, and how gene editing could help in the treatment of a rare genetic condition.Research Highlight: A gem of a material could provide a shield for spacecraftResearch Highlight: Gene editing holds promise for babies with deadly immune disease09:30 Chronic painChronic pain affects millions of people worldwide and it can be debilitating. Research into the condition has come a long way in the past few years, but this knowledge hasn’t necessarily resulted in better out